I never was someone who was at ease with happiness.

• One of the principal goals in my life has been to avoid embarrassing my children by doing the job I do. I hope I've managed to do that, and I hope that, with the job I'm in now, they are, if not proud, at least unembarrassed by it. I must say, my three are most agreeable children, who do nothing but delight me.
• Driving a motorcycle is like flying. All your senses are alive. When I ride through Beverly Hills in the early morning, and all the sprinklers have turned off, the scents that wash over me are just heavenly. Being House is like flying, too. You're free of the gravity of what people think.
• I don't have a single complete show or movie or anything else that I could look at and say, 'Nailed that one.' But endless dissatisfaction is, I suppose, what gets us out of bed in the morning.
• I feel like a hostage to fortune. Not that I am complaining. I wanted to play the role. But in truth I didn't think the show would be such a success. OK, I thought it would fail. Not because it was bad. I was confident it was good, but plenty of good things just sort of wither on the vine.
• I admit I can't shake the idea that there is virtue in suffering, that there is a sort of psychic economy, whereby if you embrace success, happiness and comfort, these things have to be paid for.
• Some people are drawn naturally - there are natural guitarists, and there are natural piano players, and I think guitar implies travel, a sort of footloose gypsy existence. You grab your bag and you go to the next town.
• Seems to me that this business, for actors anyway, is not so much about whether or not you do good work. It's about whether or not you get the chance to do good work.
• My dad gave me my first bike at 16. I soon fell off and was in a wheelchair for weeks. I haven't fallen since.
• I hate menus, I hate choosing food. I just want to be brought. Bring me dinner!
• As a real person, he wouldn't last a minute, would he? But drama is about imperfection. And we've moved away from the aspirational hero. We got tired of it, it was dull. If I was House's friend, I would hate it. How he so resolutely refuses to be happy or take the kind-hearted road. But we don't always like morally good people, do we?